Hepcidin Protects Neuron from Hemin-Mediated Injury by Reducing Iron

Hepcidin Protects Neuron from Hemin-Mediated Injury by Reducing Iron

Hemin plays a key role in mediating secondary neuronal injury after intracerebral hemorrhage (ICH) and the cell toxicity of hemin is thought to be due to iron that is liberated when hemin is degraded. In a recent study, we demonstrated the iron regulatory hormone hepcidin reduces brain iron in iron-...

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Bibliographic Details
Main Authors: Yu-Fu Zhou, Chao Zhang, Guang Yang, Zhong-Ming Qian, Meng-Wan Zhang, Juan Ma, Fa-Li Zhang, Ya Ke
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Physiology
Subjects:
hemin
intracerebral hemorrhage (ICH)
neurons
iron regulatory hormone hepcidin
apoptotic cell
ferritin
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00332/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00332/full

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