HE4 in the Differential Diagnosis of a Pelvic Mass: A Case Report
Neoplasms of the ovary present an increasing challenge to the physician. Neoplastic ovarian cysts can resemble endometriomas in ultrasound imaging and need to be carefully considered in the differential diagnosis. We report the case of a woman with a strong family history of hereditary breast and ov...
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doaj-20025ff4adef40558ae8d41e2ff72cc52020-11-25T01:08:06ZengMDPI AGInternational Journal of Molecular Sciences1422-00672011-01-0112162763210.3390/ijms12010627HE4 in the Differential Diagnosis of a Pelvic Mass: A Case ReportLuigi FratiCecilia MidullaAnna CoppaLucia ManganaroGiuseppe GianniniSara ComplojTeresa GranatoEmanuela AnastasiNeoplasms of the ovary present an increasing challenge to the physician. Neoplastic ovarian cysts can resemble endometriomas in ultrasound imaging and need to be carefully considered in the differential diagnosis. We report the case of a woman with a strong family history of hereditary breast and ovarian cancer, who presented with a pelvic mass. The young girl refused oncogenetic counseling and genetic testing, even though she had a 50% a priori probability of being a BRCA1 mutation carrier. Pelvic magnetic resonance imaging (MRI) and a comparative analysis of the serum concentration of HE-4 and CA125 biomarkers provided accuracy and sensitivity in the diagnosis of a benign ovarian pathology. Based on this experience, we propose that the sensitivity of a screening program based on a HE4 and CA125 assay and MRI in high risk patients with mutations in the BRCA1 and BRCA2 genes may be considered a useful pre-operative tool for the differential diagnosis of pelvic masses. http://www.mdpi.com/1422-0067/12/1/627/HE4 tumor markerhigh-risk patientsovarian cancerendometriosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Luigi Frati Cecilia Midulla Anna Coppa Lucia Manganaro Giuseppe Giannini Sara Comploj Teresa Granato Emanuela Anastasi |
spellingShingle |
Luigi Frati Cecilia Midulla Anna Coppa Lucia Manganaro Giuseppe Giannini Sara Comploj Teresa Granato Emanuela Anastasi HE4 in the Differential Diagnosis of a Pelvic Mass: A Case Report International Journal of Molecular Sciences HE4 tumor marker high-risk patients ovarian cancer endometriosis |
author_facet |
Luigi Frati Cecilia Midulla Anna Coppa Lucia Manganaro Giuseppe Giannini Sara Comploj Teresa Granato Emanuela Anastasi |
author_sort |
Luigi Frati |
title |
HE4 in the Differential Diagnosis of a Pelvic Mass: A Case Report |
title_short |
HE4 in the Differential Diagnosis of a Pelvic Mass: A Case Report |
title_full |
HE4 in the Differential Diagnosis of a Pelvic Mass: A Case Report |
title_fullStr |
HE4 in the Differential Diagnosis of a Pelvic Mass: A Case Report |
title_full_unstemmed |
HE4 in the Differential Diagnosis of a Pelvic Mass: A Case Report |
title_sort |
he4 in the differential diagnosis of a pelvic mass: a case report |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2011-01-01 |
description |
Neoplasms of the ovary present an increasing challenge to the physician. Neoplastic ovarian cysts can resemble endometriomas in ultrasound imaging and need to be carefully considered in the differential diagnosis. We report the case of a woman with a strong family history of hereditary breast and ovarian cancer, who presented with a pelvic mass. The young girl refused oncogenetic counseling and genetic testing, even though she had a 50% a priori probability of being a BRCA1 mutation carrier. Pelvic magnetic resonance imaging (MRI) and a comparative analysis of the serum concentration of HE-4 and CA125 biomarkers provided accuracy and sensitivity in the diagnosis of a benign ovarian pathology. Based on this experience, we propose that the sensitivity of a screening program based on a HE4 and CA125 assay and MRI in high risk patients with mutations in the BRCA1 and BRCA2 genes may be considered a useful pre-operative tool for the differential diagnosis of pelvic masses. |
topic |
HE4 tumor marker high-risk patients ovarian cancer endometriosis |
url |
http://www.mdpi.com/1422-0067/12/1/627/ |
work_keys_str_mv |
AT luigifrati he4inthedifferentialdiagnosisofapelvicmassacasereport AT ceciliamidulla he4inthedifferentialdiagnosisofapelvicmassacasereport AT annacoppa he4inthedifferentialdiagnosisofapelvicmassacasereport AT luciamanganaro he4inthedifferentialdiagnosisofapelvicmassacasereport AT giuseppegiannini he4inthedifferentialdiagnosisofapelvicmassacasereport AT saracomploj he4inthedifferentialdiagnosisofapelvicmassacasereport AT teresagranato he4inthedifferentialdiagnosisofapelvicmassacasereport AT emanuelaanastasi he4inthedifferentialdiagnosisofapelvicmassacasereport |
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