Why the Therapeutic Impact of RAS Mutation Clearance in Plasma ctDNA Deserves to Be Further Explored in Metastatic Colorectal Cancer

by Chiara Nicolazzo, Francesca Belardinilli, Salvatore Caponnetto, Angela Gradilone, Enrico Cortesi, Giuseppe Giannini, Giuseppe Giannini, Paola Gazzaniga
Published 2019-12-01

HE4 in the Differential Diagnosis of a Pelvic Mass: A Case Report

by Luigi Frati, Cecilia Midulla, Anna Coppa, Lucia Manganaro, Giuseppe Giannini, Sara Comploj, Teresa Granato, Emanuela Anastasi
Published 2011-01-01

MUC Gene Abnormalities in Sporadic and Hereditary Mucinous Colon Cancers with Microsatellite Instability

by Chiara Pastrello, Manuela Santarosa, Mara Fornasarig, Roberto Sigon, Tiziana Perin, Giuseppe Giannini, Mauro Boiocchi, Alessandra Viel
Published 2005-01-01

Galectin-3 impairment of MYCN-dependent apoptosis-sensitive phenotype is antagonized by nutlin-3 in neuroblastoma cells.

by Veronica Veschi, Marialaura Petroni, Beatrice Cardinali, Carlo Dominici, Isabella Screpanti, Luigi Frati, Armando Bartolazzi, Alberto Gulino, Giuseppe Giannini
Published 2012-01-01

MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC Cells.

by Dario Presutti, Simonetta Santini, Beatrice Cardinali, Giuliana Papoff, Cristiana Lalli, Simone Samperna, Valentina Fustaino, Giuseppe Giannini, Giovina Ruberti
Published 2015-01-01

Obinutuzumab-mediated high-affinity ligation of FcγRIIIA/CD16 primes NK cells for IFNγ production

by Cristina Capuano, Chiara Pighi, Rosa Molfetta, Rossella Paolini, Simone Battella, Gabriella Palmieri, Giuseppe Giannini, Francesca Belardinilli, Angela Santoni, Ricciarda Galandrini
Published 2017-03-01

Transient Disappearance of RAS Mutant Clones in Plasma: A Counterintuitive Clinical Use of EGFR Inhibitors in RAS Mutant Metastatic Colorectal Cancer

by Cristina Raimondi, Chiara Nicolazzo, Francesca Belardinilli, Flavia Loreni, Angela Gradilone, Yasaman Mahdavian, Alain Gelibter, Giuseppe Giannini, Enrico Cortesi, Paola Gazzaniga
Published 2019-01-01

Human Papilloma Virus-Dependent HMGA1 Expression Is a Relevant Step in Cervical Carcinogenesis

by Massimiliano Mellone, Christian Rinaldi, Isabella Massimi, Marialaura Petroni, Veronica Veschi, Claudio Talora, Silvia Truffa, Helena Stabile, Luigi Frati, Isabella Screpanti, Alberto Gulino, Giuseppe Giannini
Published 2008-08-01

Clinical Multigene Panel Sequencing Identifies Distinct Mutational Association Patterns in Metastatic Colorectal Cancer

by Francesca Belardinilli, Carlo Capalbo, Umberto Malapelle, Pasquale Pisapia, Domenico Raimondo, Edoardo Milanetti, Mahdavian Yasaman, Carlotta Liccardi, Paola Paci, Pasquale Sibilio, Francesco Pepe, Caterina Bonfiglio, Silvia Mezi, Valentina Magri, Anna Coppa, Arianna Nicolussi, Angela Gradilone, Marialaura Petroni, Stefano Di Giulio, Francesca Fabretti, Paola Infante, Sonia Coni, Gianluca Canettieri, Gianluca Canettieri, Giancarlo Troncone, Giuseppe Giannini, Giuseppe Giannini
Published 2020-05-01

Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy.

by Sonia Coni, Laura Antonucci, Davide D'Amico, Laura Di Magno, Paola Infante, Enrico De Smaele, Giuseppe Giannini, Lucia Di Marcotullio, Isabella Screpanti, Alberto Gulino, Gianluca Canettieri
Published 2013-01-01

Next-generation sequencing of BRCA1 and BRCA2 genes for rapid detection of germline mutations in hereditary breast/ovarian cancer

by Arianna Nicolussi, Francesca Belardinilli, Yasaman Mahdavian, Valeria Colicchia, Sonia D’Inzeo, Marialaura Petroni, Massimo Zani, Sergio Ferraro, Virginia Valentini, Laura Ottini, Giuseppe Giannini, Carlo Capalbo, Anna Coppa
Published 2019-04-01

New classes of potent heparanase inhibitors from ligand-based virtual screening

by Daniele Pala, Laura Scalvini, Gian Marco Elisi, Alessio Lodola, Marco Mor, Gilberto Spadoni, Fabiana F. Ferrara, Emiliano Pavoni, Giuseppe Roscilli, Ferdinando M. Milazzo, Gianfranco Battistuzzi, Silvia Rivara, Giuseppe Giannini
Published 2020-01-01

ErbB2 Targeted Epigenetic Modulation: Anti-tumor Efficacy of the ADC Trastuzumab-HDACi ST8176AA1

by Ferdinando Maria Milazzo, Loredana Vesci, Anna Maria Anastasi, Caterina Chiapparino, Antonio Rosi, Giuseppe Giannini, Maurizio Taddei, Elena Cini, Valentina Faltoni, Elena Petricci, Gianfranco Battistuzzi, Laura Salvini, Valeria Carollo, Rita De Santis
Published 2020-01-01

An Integrated Approach Identifies Nhlh1 and Insm1 as Sonic Hedgehog-regulated Genes in Developing Cerebellum and Medulloblastoma

by Enrico De Smaele, Caterina Fragomeli, Elisabetta Ferretti, Marianna Pelloni, Agnese Po, Gianluca Canettieri, Sonia Coni, Lucia Di Marcotullio, Azzura Greco, Marta Moretti, Concezio Di Rocco, Simona Pazzaglia, Marella Maroder, Isabella Screpanti, Giuseppe Giannini, Alberto Gulino
Published 2008-01-01

Transcriptome of Male Breast Cancer Matched with Germline Profiling Reveals Novel Molecular Subtypes with Possible Clinical Relevance

by Veronica Zelli, Valentina Silvestri, Virginia Valentini, Agostino Bucalo, Piera Rizzolo, Ines Zanna, Simonetta Bianchi, Anna Coppa, Giuseppe Giannini, Laura Cortesi, Daniele Calistri, Maria Grazia Tibiletti, Stephen B. Fox, kCon Fab, Domenico Palli, Laura Ottini
Published 2021-09-01

Identification of novel BRCA1 large genomic rearrangements by a computational algorithm of amplicon-based Next-Generation Sequencing data

by Arianna Nicolussi, Francesca Belardinilli, Valentina Silvestri, Yasaman Mahdavian, Virginia Valentini, Sonia D’Inzeo, Marialaura Petroni, Massimo Zani, Sergio Ferraro, Stefano Di Giulio, Francesca Fabretti, Beatrice Fratini, Angela Gradilone, Laura Ottini, Giuseppe Giannini, Anna Coppa, Carlo Capalbo
Published 2019-11-01

Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation

by Sonia Coni, Silvia Maria Serrao, Zuleyha Nihan Yurtsever, Laura Di Magno, Rosa Bordone, Camilla Bertani, Valerio Licursi, Zaira Ianniello, Paola Infante, Marta Moretti, Marialaura Petroni, Francesca Guerrieri, Alessandro Fatica, Alberto Macone, Enrico De Smaele, Lucia Di Marcotullio, Giuseppe Giannini, Marella Maroder, Enzo Agostinelli, Gianluca Canettieri
Published 2020-12-01

Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module

by Laura Di Magno, Simona Manni, Fiorella Di Pastena, Sonia Coni, Alberto Macone, Sara Cairoli, Manolo Sambucci, Paola Infante, Marta Moretti, Marialaura Petroni, Carmine Nicoletti, Carlo Capalbo, Enrico De Smaele, Lucia Di Marcotullio, Giuseppe Giannini, Luca Battistini, Bianca Maria Goffredo, Egidio Iorio, Enzo Agostinelli, Marella Maroder, Gianluca Canettieri
Published 2020-02-01

Evaluation of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk

by Piera Rizzolo, Valentina Silvestri, Virginia Valentini, Veronica Zelli, Agostino Bucalo, Ines Zanna, Simonetta Bianchi, Maria Grazia Tibiletti, Antonio Russo, Liliana Varesco, Gianluca Tedaldi, Bernardo Bonanni, Jacopo Azzollini, Siranoush Manoukian, Anna Coppa, Giuseppe Giannini, Laura Cortesi, Alessandra Viel, Marco Montagna, Paolo Peterlongo, Paolo Radice, Domenico Palli, Laura Ottini
Published 2019-08-01

A Specific Mutational Signature Associated with DNA 8-Oxoguanine Persistence in MUTYH-defective Colorectal Cancer

by Alessandra Viel, Alessandro Bruselles, Ettore Meccia, Mara Fornasarig, Michele Quaia, Vincenzo Canzonieri, Eleonora Policicchio, Emanuele Damiano Urso, Marco Agostini, Maurizio Genuardi, Emanuela Lucci-Cordisco, Tiziana Venesio, Aline Martayan, Maria Grazia Diodoro, Lupe Sanchez-Mete, Vittoria Stigliano, Filomena Mazzei, Francesca Grasso, Alessandro Giuliani, Marta Baiocchi, Roberta Maestro, Giuseppe Giannini, Marco Tartaglia, Ludmil B. Alexandrov, Margherita Bignami
Published 2017-06-01