F-Box Protein FBXO22 Mediates Polyubiquitination and Degradation of CD147 to Reverse Cisplatin Resistance of Tumor Cells

F-Box Protein FBXO22 Mediates Polyubiquitination and Degradation of CD147 to Reverse Cisplatin Resistance of Tumor Cells

Drug resistance remains a major clinical obstacle to successful treatment of cancer. As posttranslational modification is becoming widely recognized to affect the function of oncoproteins, targeting specific posttranslational protein modification provides an attractive strategy for anticancer drug d...

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Bibliographic Details
Main Authors: Bo Wu, Zhen-Yu Liu, Jian Cui, Xiang-Min Yang, Lin Jing, Yang Zhou, Zhi-Nan Chen, Jian-Li Jiang
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:International Journal of Molecular Sciences
Subjects:
CD147
FBXO22
ubiquitination
tumor
chemo-resistance
Online Access:http://www.mdpi.com/1422-0067/18/1/212

Internet

http://www.mdpi.com/1422-0067/18/1/212

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