Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex.

Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex.

Escherichia coli strains adhere to the normally sterile human uroepithelium using type 1 pili, that are long, hairy surface organelles exposing a mannose-binding FimH adhesin at the tip. A small percentage of adhered bacteria can successfully invade bladder cells, presumably via pathways mediated by...

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Bibliographic Details
Main Authors: Adinda Wellens, Corinne Garofalo, Hien Nguyen, Nani Van Gerven, Rikard Slättegård, Jean-Pierre Hernalsteens, Lode Wyns, Stefan Oscarson, Henri De Greve, Scott Hultgren, Julie Bouckaert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2323111?pdf=render

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http://europepmc.org/articles/PMC2323111?pdf=render

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