ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines

ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines

Dysfunction of the noradrenergic (NE) neurons is implicated in the pathogenesis of bipolar disorder (BPD). ErbB4 is highly expressed in NE neurons, and its genetic variation has been linked to BPD; however, how ErbB4 regulates NE neuronal function and contributes to BPD pathogenesis is unclear. Here...

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Bibliographic Details
Main Authors: Shu-Xia Cao, Ying Zhang, Xing-Yue Hu, Bin Hong, Peng Sun, Hai-Yang He, Hong-Yan Geng, Ai-Min Bao, Shu-Min Duan, Jian-Ming Yang, Tian-Ming Gao, Hong Lian, Xiao-Ming Li
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-09-01
Series:eLife
Subjects:
ErbB4
noradrenergic neuron
Locus coeruleus
mania
bipolar disorder
Online Access:https://elifesciences.org/articles/39907

Internet

https://elifesciences.org/articles/39907

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