The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells.

The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells.

TP53 is the most commonly mutated gene in head and neck cancer (HNSCC), with mutations being associated with resistance to conventional therapy. Restoring normal p53 function has previously been investigated via the use of RITA (reactivation of p53 and induction of tumor cell apoptosis), a small mol...

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Bibliographic Details
Main Authors: Hui-Ching Chuang, Liang Peng Yang, Alison L Fitzgerald, Abdullah Osman, Sang Hyeok Woo, Jeffrey N Myers, Heath D Skinner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4132078?pdf=render

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http://europepmc.org/articles/PMC4132078?pdf=render

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