Dopaminergic Neuromodulation of Spike Timing Dependent Plasticity in Mature Adult Rodent and Human Cortical Neurons

Dopaminergic Neuromodulation of Spike Timing Dependent Plasticity in Mature Adult Rodent and Human Cortical Neurons

Synapses in the cerebral cortex constantly change and this dynamic property regulated by the action of neuromodulators such as dopamine (DA), is essential for reward learning and memory. DA modulates spike-timing-dependent plasticity (STDP), a cellular model of learning and memory, in juvenile roden...

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Bibliographic Details
Main Authors: Emma Louise Louth, Rasmus Langelund Jørgensen, Anders Rosendal Korshoej, Jens Christian Hedemann Sørensen, Marco Capogna
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
dopamine
human cortical slices
layer 5 pyramidal neurons
spike timing dependent plasticity
synaptic inhibition
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.668980/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2021.668980/full

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