Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation

Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation

One of the key questions in biology is how the metabolism of a cell responds to changes in the environment. In budding yeast, starvation causes a drop in intracellular pH, but the functional role of this pH change is not well understood. Here, we show that the enzyme glutamine synthetase (Gln1) form...

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Bibliographic Details
Main Authors: Ivana Petrovska, Elisabeth Nüske, Matthias C Munder, Gayathrie Kulasegaran, Liliana Malinovska, Sonja Kroschwald, Doris Richter, Karim Fahmy, Kimberley Gibson, Jean-Marc Verbavatz, Simon Alberti
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-04-01
Series:eLife
Subjects:
metabolic enzyme
metabolism
intracellular pH
protein aggregation
macromolecular crowding
quiescence
Online Access:https://elifesciences.org/articles/02409

Internet

https://elifesciences.org/articles/02409

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