CIC Is a Mediator of the ERK1/2-DUSP6 Negative Feedback Loop

CIC Is a Mediator of the ERK1/2-DUSP6 Negative Feedback Loop

Summary: DUSP6 functions as an important negative feedback component of the MAPK/ERK signaling pathway. Although DUSP6 expression is tightly regulated by ERK1/2 signaling, the molecular mechanism of this regulation remains partially understood. In this work, we show that the transcriptional represso...

Full description

Bibliographic Details
Main Authors: Yibo Ren, Zhenlin Ouyang, Zhanwu Hou, Yuwei Yan, Zhe Zhi, Mengjin Shi, Mengtao Du, Huadong Liu, Yurong Wen, Yongping Shao
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:iScience
Subjects:
Biochemistry
Structural Biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220308270

Internet

http://www.sciencedirect.com/science/article/pii/S2589004220308270

Similar Items