Persistent cAMP-signals triggered by internalized G-protein-coupled receptors.

Persistent cAMP-signals triggered by internalized G-protein-coupled receptors.

G-protein-coupled receptors (GPCRs) are generally thought to signal to second messengers like cyclic AMP (cAMP) from the cell surface and to become internalized upon repeated or prolonged stimulation. Once internalized, they are supposed to stop signaling to second messengers but may trigger nonclas...

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Bibliographic Details
Main Authors: Davide Calebiro, Viacheslav O Nikolaev, Maria Cristina Gagliani, Tiziana de Filippis, Christian Dees, Carlo Tacchetti, Luca Persani, Martin J Lohse
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2718703?pdf=render

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http://europepmc.org/articles/PMC2718703?pdf=render

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