Preparation of Solid Dispersions of Simvastatin and Soluplus Using a Single-Step Organic Solvent-Free Supercritical Fluid Process for the Drug Solubility and Dissolution Rate Enhancement

Preparation of Solid Dispersions of Simvastatin and Soluplus Using a Single-Step Organic Solvent-Free Supercritical Fluid Process for the Drug Solubility and Dissolution Rate Enhancement

The study was designed to investigate the feasibility of supercritical carbon dioxide (scCO<sub>2</sub>) processing for the preparation of simvastatin (SIM) solid dispersions (SDs) in Soluplus<sup>®</sup> (SOL) at temperatures below polymer’s glass transition. The SIM content...

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Bibliographic Details
Main Authors: Uttom Nandi, Adejumoke Lara Ajiboye, Preksha Patel, Dennis Douroumis, Vivek Trivedi
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceuticals
Subjects:
simvastatin
supercritical carbon dioxide
soluplus
drug dissolution
Online Access:https://www.mdpi.com/1424-8247/14/9/846

Internet

https://www.mdpi.com/1424-8247/14/9/846

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