Unbiased Metagenomic Sequencing for Pediatric Meningitis in Bangladesh Reveals Neuroinvasive Chikungunya Virus Outbreak and Other Unrealized Pathogens

Unbiased Metagenomic Sequencing for Pediatric Meningitis in Bangladesh Reveals Neuroinvasive Chikungunya Virus Outbreak and Other Unrealized Pathogens

Globally, there are an estimated 10.6 million cases of meningitis and 288,000 deaths every year, with the vast majority occurring in low- and middle-income countries. In addition, many survivors suffer from long-term neurological sequelae. Most laboratories assay only for common bacterial etiologies...

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Bibliographic Details
Main Authors: Senjuti Saha, Akshaya Ramesh, Katrina Kalantar, Roly Malaker, Md Hasanuzzaman, Lillian M. Khan, Madeline Y. Mayday, M. S. I. Sajib, Lucy M. Li, Charles Langelier, Hafizur Rahman, Emily D. Crawford, Cristina M. Tato, Maksuda Islam, Yun-Fang Juan, Charles de Bourcy, Boris Dimitrov, James Wang, Jennifer Tang, Jonathan Sheu, Rebecca Egger, Tiago Rodrigues De Carvalho, Michael R. Wilson, Samir K. Saha, Joseph L. DeRisi
Format: Article
Language:English
Published: American Society for Microbiology 2019-12-01
Series:mBio
Subjects:
idiopathic meningitis
metagenomics
etiology
bangladesh
cerebrospinal fluid
chikungunya virus
meningitis
virology
Online Access:https://doi.org/10.1128/mBio.02877-19

Internet

https://doi.org/10.1128/mBio.02877-19

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