The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness

The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness

Abstract Background Disruptor of telomeric silencing 1-like (DOT1L) is a non-SET domain containing methyltransferase known to catalyze mono-, di-, and tri-methylation of histone 3 on lysine 79 (H3K79me). DOT1L-mediated H3K79me has been implicated in chromatin-associated functions including gene tran...

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Bibliographic Details
Main Authors: Vijayalakshmi Kari, Sanjay Kumar Raul, Jana Maria Henck, Julia Kitz, Frank Kramer, Robyn Laura Kosinsky, Nadine Übelmesser, Wael Yassin Mansour, Jessica Eggert, Melanie Spitzner, Zeynab Najafova, Holger Bastians, Marian Grade, Jochen Gaedcke, Florian Wegwitz, Steven A. Johnsen
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Clinical Epigenetics
Subjects:
DOT1L
H3K79me
γH2AX
DNA damage
DNA double-strand breaks
Homologous recombination
Online Access:http://link.springer.com/article/10.1186/s13148-018-0601-1

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http://link.springer.com/article/10.1186/s13148-018-0601-1

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