Transcriptomic Profiles of CD47 in Breast Tumors Predict Outcome and Are Associated with Immune Activation

Transcriptomic Profiles of CD47 in Breast Tumors Predict Outcome and Are Associated with Immune Activation

Targeting the innate immune system has attracted attention with the development of anti- CD47 antibodies. Anti-CD47 antibodies block the inhibition of the phagocytic activity of macrophages caused by the up-regulation of CD47 on tumor cells. In this study, public genomic data was used to identify ge...

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Bibliographic Details
Main Authors: María del Mar Noblejas-López, Mariona Baliu-Piqué, Cristina Nieto-Jiménez, Francisco J. Cimas, Esther C. Morafraile, Atanasio Pandiella, Ángel L. Corbi, Balázs Győrffy, Alberto Ocaña
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
CD47
immune activation
pro-tumoral macrophages
immunotherapy
breast cancer
Online Access:https://www.mdpi.com/1422-0067/22/8/3836

Internet

https://www.mdpi.com/1422-0067/22/8/3836

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