Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa

Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa

Current treatments for Pseudomonas aeruginosa infections are becoming less effective because of the increasing rates of multi-antibiotic resistance. Pharmacological targeting of virulence through inhibition of quorum sensing (QS) dependent virulence gene regulation has considerable therapeutic poten...

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Bibliographic Details
Main Authors: Fadi Soukarieh, Ruiling Liu, Manuel Romero, Shaun N. Roberston, William Richardson, Simone Lucanto, Eduard Vico Oton, Naim Ruhul Qudus, Alaa Mashabi, Scott Grossman, Sadiqur Ali, Tomás Sou, Irena Kukavica-Ibrulj, Roger C. Levesque, Christel A. S. Bergström, Nigel Halliday, Shailesh N. Mistry, Jonas Emsley, Stephan Heeb, Paul Williams, Miguel Cámara, Michael J. Stocks
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Chemistry
Subjects:
Pseudomonas aeruginosa
PqsR
MvfR
Pseudomonas quinolone signal (PQS)
alkylquinolone
biofilms
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00204/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2020.00204/full

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