Targeting Premature Renal Aging: from Molecular Mechanisms of Cellular Senescence to Senolytic Trials

Targeting Premature Renal Aging: from Molecular Mechanisms of Cellular Senescence to Senolytic Trials

The biological process of renal aging is characterized by progressive structural and functional deterioration of the kidney leading to end-stage renal disease, requiring renal replacement therapy. Since the discovery of pivotal mechanisms of senescence such as cell cycle arrest, apoptosis inhibition...

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Bibliographic Details
Main Authors: Rossana Franzin, Alessandra Stasi, Elena Ranieri, Giuseppe Stefano Netti, Vincenzo Cantaluppi, Loreto Gesualdo, Giovanni Stallone, Giuseppe Castellano
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
senescence
renal ageing
mitochondrial dysfunction
DNA damage repair
extracellular vesicles
senolytics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.630419/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.630419/full

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