FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21

FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21

Abstract Background Deregulation of ubiquitin ligases is related to the malignant progression of human cancers. F-box only protein 22 (FBXO22), an F-box E3 ligase, is a member of the F-box protein family. However, the biological function of FBXO22 in HCC and the underlying molecular mechanisms are s...

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Bibliographic Details
Main Authors: Long Zhang, Jin Chen, Deng Ning, Qiumeng Liu, Chao Wang, Zhaoqi Zhang, Liang Chu, Chengpeng Yu, Hui-fang Liang, Bixiang Zhang, Xiaoping Chen
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
FBXO22
Ubiquitination
p21
HCC
Online Access:http://link.springer.com/article/10.1186/s13046-019-1058-6

Internet

http://link.springer.com/article/10.1186/s13046-019-1058-6

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