Whole-Organ Genomic Characterization of Mucosal Field Effects Initiating Bladder Carcinogenesis

Whole-Organ Genomic Characterization of Mucosal Field Effects Initiating Bladder Carcinogenesis

Summary: We used whole-organ mapping to study the locoregional molecular changes in a human bladder containing multifocal cancer. Widespread DNA methylation changes were identified in the entire mucosa, representing the initial field effect. The field effect was associated with subclonal low-allele...

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Bibliographic Details
Main Authors: Tadeusz Majewski, Hui Yao, Jolanta Bondaruk, Woonbok Chung, Sangkyou Lee, June Goo Lee, Shizhen Zhang, David Cogdell, Guoliang Yang, Woonyoung Choi, Colin Dinney, H. Barton Grossman, Christopher Logothetis, Steven E. Scherer, Charles C. Guo, Li Zhang, Peng Wei, John N. Weinstein, Jean-Pierre Issa, Keith Baggerly, David J. McConkey, Bogdan Czerniak
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719301329

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http://www.sciencedirect.com/science/article/pii/S2211124719301329

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