Whole-Organ Genomic Characterization of Mucosal Field Effects Initiating Bladder Carcinogenesis
Summary: We used whole-organ mapping to study the locoregional molecular changes in a human bladder containing multifocal cancer. Widespread DNA methylation changes were identified in the entire mucosa, representing the initial field effect. The field effect was associated with subclonal low-allele...
Main Authors: | Tadeusz Majewski, Hui Yao, Jolanta Bondaruk, Woonbok Chung, Sangkyou Lee, June Goo Lee, Shizhen Zhang, David Cogdell, Guoliang Yang, Woonyoung Choi, Colin Dinney, H. Barton Grossman, Christopher Logothetis, Steven E. Scherer, Charles C. Guo, Li Zhang, Peng Wei, John N. Weinstein, Jean-Pierre Issa, Keith Baggerly, David J. McConkey, Bogdan Czerniak |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2019-02-01
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Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124719301329 |
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