Human Bone Marrow-Derived Myeloid Dendritic Cells Show an Immature Transcriptional and Functional Profile Compared to Their Peripheral Blood Counterparts and Separate from Slan+ Non-Classical Monocytes

Human Bone Marrow-Derived Myeloid Dendritic Cells Show an Immature Transcriptional and Functional Profile Compared to Their Peripheral Blood Counterparts and Separate from Slan+ Non-Classical Monocytes

The human bone marrow (BM) gives rise to all distinct blood cell lineages, including CD1c+ (cDC2) and CD141+ (cDC1) myeloid dendritic cells (DC) and monocytes. These cell subsets are also present in peripheral blood (PB) and lymphoid tissues. However, the difference between the BM and PB compartment...

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Bibliographic Details
Main Authors: Nathalie van Leeuwen-Kerkhoff, Kristina Lundberg, Theresia M. Westers, Shahram Kordasti, Hetty J. Bontkes, Malin Lindstedt, Tanja D. de Gruijl, Arjan A. van de Loosdrecht
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
dendritic cells
non-classical monocytes
bone marrow
peripheral blood
microarray analysis
cytokines
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01619/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01619/full

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