Impairment of the Hypothalamus–Pituitary–Thyroid Axis Caused by Naturally Occurring <i>GATA2</i> Mutations In Vitro

Impairment of the Hypothalamus–Pituitary–Thyroid Axis Caused by Naturally Occurring <i>GATA2</i> Mutations In Vitro

The transcription factor GATA2 regulates gene expression in several cells and tissues, including hematopoietic tissues and the central nervous system. Recent studies revealed that loss-of-function mutations in <i>GATA2</i> are associated with hematological disorders. Our earlier in vitro...

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Bibliographic Details
Main Authors: Yuki Sakai, Kenji Ohba, Shigekazu Sasaki, Akio Matsushita, Hiroko Misawa Nakamura, Go Kuroda, Daisuke Tsuriya, Miho Yamashita, Takafumi Suda
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
GATA
thyroid
central hypothyroidism
hypothalamus–pituitary–thyroid axis (HPT axis)
haploinsufficiency
Online Access:https://www.mdpi.com/1422-0067/22/18/10015

Internet

https://www.mdpi.com/1422-0067/22/18/10015

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