Gαi Proteins are Indispensable for Hearing

Gαi Proteins are Indispensable for Hearing

Background/Aims: From invertebrates to mammals, Gαi proteins act together with their common binding partner Gpsm2 to govern cell polarization and planar organization in virtually any polarized cell. Recently, we demonstrated that Gαi3-deficiency in pre-hearing murine cochleae pointed to a role of Gα...

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Bibliographic Details
Main Authors: Sandra Beer-Hammer, Sze Chim Lee, Stephanie A. Mauriac, Veronika Leiss, Isabel A. M. Groh, Ana Novakovic, Roland P. Piekorz, Kirsten Bucher, Chengfang Chen, Kun Ni, Wibke Singer, Csaba Harasztosi, Thomas Schimmang, Ulrike Zimmermann, Klaus Pfeffer, Lutz Birnbaumer, Andrew Forge, Mireille Montcouquiol, Marlies Knipper, Bernd Nürnberg, Lukas Rüttiger
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Heterotrimeric G-proteins
Gαi3/GNAI3
Stereocilia bundle
Cochlear hair cell maturation
Neural gain
Deafness gene
Online Access:https://www.karger.com/Article/FullText/490867

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https://www.karger.com/Article/FullText/490867

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