Superiority of Formalin-Fixed Paraffin-Embedded Brain Tissue for in vitro Assessment of Progressive Supranuclear Palsy Tau Pathology With [18F]PI-2620

Superiority of Formalin-Fixed Paraffin-Embedded Brain Tissue for in vitro Assessment of Progressive Supranuclear Palsy Tau Pathology With [18F]PI-2620

Objectives: Autoradiography on brain tissue is used to validate binding targets of newly discovered radiotracers. The purpose of this study was to correlate quantification of autoradiography signal using the novel next-generation tau positron emission tomography (PET) radiotracer [18F]PI-2620 with i...

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Bibliographic Details
Main Authors: Marie Willroider, Sigrun Roeber, Anja K. E. Horn, Thomas Arzberger, Maximilian Scheifele, Gesine Respondek, Osama Sabri, Henryk Barthel, Marianne Patt, Olena Mishchenko, Andreas Schildan, André Mueller, Norman Koglin, Andrew Stephens, Johannes Levin, Günter U. Höglinger, Peter Bartenstein, Jochen Herms, Matthias Brendel, Leonie Beyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Neurology
Subjects:
tau
autoradiography
immunohistochemistry
progressive supranuclear palsy
PI-2620
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.684523/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2021.684523/full

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