Co-infusion of haplo-identical CD19-chimeric antigen receptor T cells and stem cells achieved full donor engraftment in refractory acute lymphoblastic leukemia

Co-infusion of haplo-identical CD19-chimeric antigen receptor T cells and stem cells achieved full donor engraftment in refractory acute lymphoblastic leukemia

Abstract Background Elderly patients with relapsed and refractory acute lymphoblastic leukemia (ALL) have poor prognosis. Autologous CD19 chimeric antigen receptor-modified T (CAR-T) cells have potentials to cure patients with B cell ALL; however, safety and efficacy of allogeneic CD19 CAR-T cells a...

Full description

Bibliographic Details
Main Authors: Bo Cai, Mei Guo, Yao Wang, Yajing Zhang, Jun Yang, Yelei Guo, Hanren Dai, Changlin Yu, Qiyun Sun, Jianhui Qiao, Kaixun Hu, Hongli Zuo, Zheng Dong, Zechuan Zhang, Mingxing Feng, Bingxia Li, Yujing Sun, Tieqiang Liu, Zhiqing Liu, Yi Wang, Yajing Huang, Bo Yao, Weidong Han, Huisheng Ai
Format: Article
Language:English
Published: BMC 2016-11-01
Series:Journal of Hematology & Oncology
Subjects:
Allogeneic anti-CD19 chimeric antigen receptor (CAR) T cells
Haplo-identical mobilized peripheral blood stem cell infusion
B cell acute lymphoblastic leukemia (B-ALL)
Relapsed and refractory
Case report
Online Access:http://link.springer.com/article/10.1186/s13045-016-0357-z

Internet

http://link.springer.com/article/10.1186/s13045-016-0357-z

Similar Items