Insulin receptor substrate-1 prevents autophagy-dependent cell death caused by oxidative stress in mouse NIH/3T3 cells

Insulin receptor substrate-1 prevents autophagy-dependent cell death caused by oxidative stress in mouse NIH/3T3 cells

<p>Abstract</p> <p>Background</p> <p>Insulin receptor substrate (IRS)-1 is associated with tumorigenesis; its levels are elevated in several human cancers. IRS-1 protein binds to several oncogene proteins. Oxidative stress and reactive oxygen species (ROS) are involved...

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Bibliographic Details
Main Authors: Chan Shih-Hung, Kikkawa Ushio, Matsuzaki Hidenori, Chen Jyh-Hong, Chang Wen-Chang
Format: Article
Language:English
Published: BMC 2012-07-01
Series:Journal of Biomedical Science
Subjects:
Insulin receptor substrate
Oxidative stress
Autophagy
Cell death
Cancer
Mammalian target of rapamycin
p70 ribosomal protein S6 kinase
Reactive oxygen species
Glucose oxidase
Online Access:http://www.jbiomedsci.com/content/19/1/64

Internet

http://www.jbiomedsci.com/content/19/1/64

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