The Shigella Type III Secretion Effector IpaH4.5 Targets NLRP3 to Activate Inflammasome Signaling

The Shigella Type III Secretion Effector IpaH4.5 Targets NLRP3 to Activate Inflammasome Signaling

Activation of the NLRP3 inflammasome requires the expression of NLRP3, which is strictly regulated by its capacity to directly recognize microbial-derived substances. Even though the involvement of caspase-1 activation in macrophages via NLRP3 and NLRC4 has been discovered, the accurate mechanisms b...

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Bibliographic Details
Main Authors: Xiaolin Wang, Jin Sun, Luming Wan, Xiaopan Yang, Haotian Lin, Yanhong Zhang, Xiang He, Hui Zhong, Kai Guan, Min Min, Zhenxue Sun, Xiaoli Yang, Bin Wang, Mingxin Dong, Congwen Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Shigella
IpaH4.5
NLRP3
inflammasome
T3SS
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.511798/full

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https://www.frontiersin.org/article/10.3389/fcimb.2020.511798/full

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