Enrichment technique to allow early detection and monitor emergence of KRAS mutation in response to treatment

Enrichment technique to allow early detection and monitor emergence of KRAS mutation in response to treatment

Abstract Sensitivity of cell-free circulating tumour DNA (ctDNA) assays is often hampered by the limited quantity of intact mutant nucleotide fragments. To overcome the issue of substrate limitation in clinical applications, we developed an enrichment method utilizing pyrrole-imidazole (PI) polyamid...

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Main Authors: Yoshiyasu Kitagawa, Kazuhiro Okumura, Takayoshi Watanabe, Kei Tsukamoto, Shiro Kitano, Rino Nankinzan, Takuto Suzuki, Taro Hara, Hiroaki Soda, Tadamichi Denda, Taketo Yamaguchi, Hiroki Nagase
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-019-47700-9

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https://doi.org/10.1038/s41598-019-47700-9

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