Oxidation of HDAC4 by Nox4-derived H2O2 maintains tube formation by endothelial cells

Oxidation of HDAC4 by Nox4-derived H2O2 maintains tube formation by endothelial cells

NADPH oxidases produce reactive oxygen species that differ in localization, type and concentration. Within the Nox family only Nox4 produces H2O2 which can directly oxidize cysteine residues. With this post-translational modification, activity, stability, localization and protein-protein interaction...

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Bibliographic Details
Main Authors: Tim Schader, Oliver Löwe, Christina Reschke, Pedro Malacarne, Fabian Hahner, Niklas Müller, Anna Gajos-Draus, Johannes Backs, Katrin Schröder
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Redox Biology
Subjects:
NADPH oxidase
Nox4
HDAC4
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720308740

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http://www.sciencedirect.com/science/article/pii/S2213231720308740

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