Metformin Therapy Effects on the Expression of Sodium-Glucose Cotransporter 2, Leptin, and SIRT6 Levels in Pericoronary Fat Excised from Pre-Diabetic Patients with Acute Myocardial Infarction

Metformin Therapy Effects on the Expression of Sodium-Glucose Cotransporter 2, Leptin, and SIRT6 Levels in Pericoronary Fat Excised from Pre-Diabetic Patients with Acute Myocardial Infarction

Background and purpose: pericoronary fat over-inflammation might lead to the development and destabilization of coronary plaque in patients with pre-diabetes (PDM). Notably, pericoronary fat could over-express the sodium-glucose cotransporter 2 (SGLT2) and leptin, along with decreased sirtuin 6 (SIR...

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Main Authors: Celestino Sardu, Nunzia D’Onofrio, Michele Torella, Michele Portoghese, Simone Mureddu, Francesco Loreni, Franca Ferraraccio, Iacopo Panarese, Maria Consiglia Trotta, Gianluca Gatta, Marilena Galdiero, Ferdinando Carlo Sasso, Michele D’Amico, Marisa De Feo, Maria Luisa Balestrieri, Giuseppe Paolisso, Raffaele Marfella
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Biomedicines
Subjects:
pre-diabetes
acute myocardial infarction
metformin
pericoronary fat
sodium-glucose cotransporter 2 protein
leptin
Online Access:https://www.mdpi.com/2227-9059/9/8/904

Internet

https://www.mdpi.com/2227-9059/9/8/904

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