Anti-tumor efficacy of a combination therapy with PD-L1 targeted alpha therapy and adoptive cell transfer of PD-1 deficient melanoma-specific human T-lymphocytes

Anti-tumor efficacy of a combination therapy with PD-L1 targeted alpha therapy and adoptive cell transfer of PD-1 deficient melanoma-specific human T-lymphocytes

The optimization of adoptive transfer approaches of anti-tumor T cells requires both the functional improvement of the injected T cells and the modulation of the tumor microenvironment, favoring the recruitment of these T cells and their activation. We have recently shown the therapeutic benefit of...

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Bibliographic Details
Main Authors: L Marotte, M Capitao, C Deleine, T Beauvais, G Cadiou, J. Perrin, M Chérel, E Scotet, Y Guilloux, F Bruchertseifer, A Morgenstern, A Jarry, J. Gaschet, N Labarriere
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
pd-1
pd-l1
targeted alpha therapy
melanoma
adoptive cell transfer
gene editing
Online Access:http://dx.doi.org/10.1080/2162402X.2021.1940676

Internet

http://dx.doi.org/10.1080/2162402X.2021.1940676

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