NLRP3 Inflammasome Activation of Mast Cells by Estrogen via the Nuclear-Initiated Signaling Pathway Contributes to the Development of Endometriosis

NLRP3 Inflammasome Activation of Mast Cells by Estrogen via the Nuclear-Initiated Signaling Pathway Contributes to the Development of Endometriosis

Endometriosis is an estrogen-dependent gynecological disease. The pathogenesis of endometriosis remains controversial, although it is generally accepted that the inflammatory immune response plays a crucial role in this process. Mast cells (MCs) are multifunctional innate immune cells that accumulat...

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Bibliographic Details
Main Authors: Xinyue Guo, Xinxin Xu, Tiantian Li, Qin Yu, Jianzhang Wang, Yichen Chen, Shaojie Ding, Libo Zhu, Gen Zou, Xinmei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
endometriosis
estrogen
mast cells
NLRP3 inflammasome
interleukin-1β
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.749979/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.749979/full

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