Drug-induced epigenetic changes produce drug tolerance.
Tolerance to drugs that affect neural activity is mediated, in part, by adaptive mechanisms that attempt to restore normal neural excitability. Changes in the expression of ion channel genes are thought to play an important role in these neural adaptations. The slo gene encodes the pore-forming subu...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2007-10-01
|
| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC2020501?pdf=render |