Characterization of secretory sphingomyelinase activity, lipoprotein sphingolipid content and LDL aggregation in ldlr−/− mice fed on a high-fat diet

Characterization of secretory sphingomyelinase activity, lipoprotein sphingolipid content and LDL aggregation in ldlr−/− mice fed on a high-fat diet

The propensity of LDLs (low-density lipoproteins) for aggregation and/or oxidation has been linked to their sphingolipid content, specifically the levels of SM (sphingomyelin) and ceramide. To investigate this association in vivo, ldlr (LDL receptor)-null mice (ldlr−/−) were fe...

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Bibliographic Details
Main Authors: Gergana M. Deevska, Manjula Sunkara, Andrew J. Morris, Mariana N. Nikolova‑Karakashian
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2012-08-01
Series:Bioscience Reports
Subjects:
atherosclerosis
ceramide
low-density lipoprotein aggregation
sphingomyelin
secretory sphingomyelinase
Online Access:http://www.bioscirep.org/bsr/032/0479/bsr0320479.htm

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http://www.bioscirep.org/bsr/032/0479/bsr0320479.htm

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