The temporal mutational and immune tumour microenvironment remodelling of HER2-negative primary breast cancers

The temporal mutational and immune tumour microenvironment remodelling of HER2-negative primary breast cancers

Abstract The biology of breast cancer response to neoadjuvant therapy is underrepresented in the literature and provides a window-of-opportunity to explore the genomic and microenvironment modulation of tumours exposed to therapy. Here, we characterised the mutational, gene expression, pathway enric...

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Main Authors: Leticia De Mattos-Arruda, Javier Cortes, Juan Blanco-Heredia, Daniel G. Tiezzi, Guillermo Villacampa, Samuel Gonçalves-Ribeiro, Laia Paré, Carla Anjos Souza, Vanesa Ortega, Stephen-John Sammut, Pol Cusco, Roberta Fasani, Suet-Feung Chin, Jose Perez-Garcia, Rodrigo Dienstmann, Paolo Nuciforo, Patricia Villagrasa, Isabel T. Rubio, Aleix Prat, Carlos Caldas
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-021-00282-0

Internet

https://doi.org/10.1038/s41523-021-00282-0

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