The H<sub>2</sub>S Donor GYY4137 Stimulates Reactive Oxygen Species Generation in BV2 Cells While Suppressing the Secretion of TNF and Nitric Oxide

The H<sub>2</sub>S Donor GYY4137 Stimulates Reactive Oxygen Species Generation in BV2 Cells While Suppressing the Secretion of TNF and Nitric Oxide

GYY4137 is a hydrogen sulfide (H<sub>2</sub>S) donor that has been shown to act in an anti-inflammatory manner in vitro and in vivo. Microglial cells are among the major players in immunoinflammatory, degenerative, and neoplastic disorders of the central nervous system, including multipl...

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Bibliographic Details
Main Authors: Milica Lazarević, Emanuela Mazzon, Miljana Momčilović, Maria Sofia Basile, Giuseppe Colletti, Maria Cristina Petralia, Placido Bramanti, Ferdinando Nicoletti, Đorđe Miljković
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
hydrogen sulfide
GYY4137
microglia
reactive oxygen species
inflammation
Online Access:https://www.mdpi.com/1420-3049/23/11/2966

Internet

https://www.mdpi.com/1420-3049/23/11/2966

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