APOBEC3B Activity Is Prevalent in Urothelial Carcinoma Cells and Only Slightly Affected by LINE-1 Expression

APOBEC3B Activity Is Prevalent in Urothelial Carcinoma Cells and Only Slightly Affected by LINE-1 Expression

The most common mutational signature in urothelial carcinoma (UC), the most common type of urinary bladder cancer is assumed to be caused by the misdirected activity of APOBEC3 (A3) cytidine deaminases, especially A3A or A3B, which are known to normally restrict the propagation of exogenous viruses...

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Bibliographic Details
Main Authors: Ananda Ayyappan Jaguva Vasudevan, Ulrike Kreimer, Wolfgang A. Schulz, Aikaterini Krikoni, Gerald G. Schumann, Dieter Häussinger, Carsten Münk, Wolfgang Goering
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Microbiology
Subjects:
cytidine deaminase
APOBEC3B
APOBEC3G
APOBEC3H
urothelial cancer cells
LINE-1
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02088/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.02088/full

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