The G1613A mutation in the HBV genome affects HBeAg expression and viral replication through altered core promoter activity.

The G1613A mutation in the HBV genome affects HBeAg expression and viral replication through altered core promoter activity.

Infection of hepatitis B virus (HBV) causes acute and chronic hepatitis and is closely associated with the development of cirrhosis and hepatocellular carcinoma (HCC). Previously, we demonstrated that the G1613A mutation in the HBV negative regulatory element (NRE) is a hotspot mutation in HCC patie...

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Bibliographic Details
Main Authors: Man-Shan Li, Terrence Chi-Kong Lau, Sophie Ka-Ping Chan, Chi-Hang Wong, Patrick Kwok-Shing Ng, Joseph Jao-Yiu Sung, Henry Lik-Yuen Chan, Stephen Kwok-Wing Tsui
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3140978?pdf=render

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http://europepmc.org/articles/PMC3140978?pdf=render

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