Indirect Impact of PD-1/PD-L1 Blockade on a Murine Model of NK Cell Exhaustion

Indirect Impact of PD-1/PD-L1 Blockade on a Murine Model of NK Cell Exhaustion

The induction of exhaustion on effector immune cells is an important limiting factor for cancer immunotherapy efficacy as these cells undergo a hierarchical loss of proliferation and cytolytic activity due to chronic stimulation. Targeting PD-1 has shown unprecedented clinical benefits for many canc...

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Bibliographic Details
Main Authors: Maite Alvarez, Federico Simonetta, Jeanette Baker, Alyssa R. Morrison, Arielle S. Wenokur, Antonio Pierini, Pedro Berraondo, Robert S. Negrin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
NK
exhaustion
chronic stimulation
PD-1/PD-L1 pathway
CD8
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00007/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00007/full

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