Edema Induced by a Crotalus durissus terrificus Venom Serine Protease (Cdtsp 2) Involves the PAR Pathway and PKC and PLC Activation

Edema Induced by a Crotalus durissus terrificus Venom Serine Protease (Cdtsp 2) Involves the PAR Pathway and PKC and PLC Activation

Snake venom serine proteases (SVSPs) represent an essential group of enzymatic toxins involved in several pathophysiological effects on blood homeostasis. Some findings suggest the involvement of this class of enzymatic toxins in inflammation. In this paper, we purified and isolated a new gyroxin is...

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Bibliographic Details
Main Authors: Caroline R. C. Costa, Mariana Novo Belchor, Caroline F. B. Rodrigues, Daniela de Oliveira Toyama, Marcos A. de Oliveira, Danielle P. Novaes, Marcos Hikari Toyama
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
snake venom serine protease
Crotalus durissus terrificus (Cdt)
edema
inflammation
oxidative stress
protease-activated receptor
COX-2
MDA
Online Access:http://www.mdpi.com/1422-0067/19/8/2405

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http://www.mdpi.com/1422-0067/19/8/2405

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