Two novel amino acid substitutions in highly conserved regions of prion protein (PrP) and a high frequency of a scrapie protective variant in native Ethiopian goats

Two novel amino acid substitutions in highly conserved regions of prion protein (PrP) and a high frequency of a scrapie protective variant in native Ethiopian goats

Abstract Background Polymorphisms of the prion protein gene may influence scrapie susceptibility in small ruminants through modified protein conformation. At least 47 amino acid substitutions and 19 silent polymorphisms have been described in goat PRNP reported from several countries. The objective...

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Bibliographic Details
Main Authors: Maria Vitale, Sergio Migliore, Berhanu Tilahun, Mukarim Abdurahaman, Marco Tolone, Ignazio Sammarco, Vincenzo Di Marco Lo Presti, Endrias Zewdu Gebremedhin
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Veterinary Research
Subjects:
Ethiopian native goats; novel polymorphisms
PRNP
PrP
Scrapie
Online Access:http://link.springer.com/article/10.1186/s12917-019-1870-4

Internet

http://link.springer.com/article/10.1186/s12917-019-1870-4

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