Mathematical Modeling Reveals That the Administration of EGF Can Promote the Elimination of Lymph Node Metastases by PD-1/PD-L1 Blockade

Mathematical Modeling Reveals That the Administration of EGF Can Promote the Elimination of Lymph Node Metastases by PD-1/PD-L1 Blockade

In the advanced stages of cancers like melanoma, some of the malignant cells leave the primary tumor and infiltrate the neighboring lymph nodes (LNs). The interaction between secondary cancer and the immune response in the lymph node represents a complex process that needs to be fully understood in...

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Bibliographic Details
Main Authors: Mohamed Amine Benchaib, Anass Bouchnita, Vitaly Volpert, Abdelkader Makhoute
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
PD-1/PD-L1
immune response
cancer immune interaction
hybrid modeling
multiscale modeling
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00104/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2019.00104/full

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