Novel Rhodanine Derivative, 5-[4-(4-Fluorophenoxy) phenyl]methylene-3-{4-[3-(4-methylpiperazin-1-yl) propoxy]phenyl}-2-thioxo-4-thiazolidinone dihydrochloride, Induces Apoptosis via Mitochondria Dysfunction and Endoplasmic Reticulum Stress in Human Colon Cancer Cells

Novel Rhodanine Derivative, 5-[4-(4-Fluorophenoxy) phenyl]methylene-3-{4-[3-(4-methylpiperazin-1-yl) propoxy]phenyl}-2-thioxo-4-thiazolidinone dihydrochloride, Induces Apoptosis via Mitochondria Dysfunction and Endoplasmic Reticulum Stress in Human Colon Cancer Cells

We previously reported that 5-[4-(4-fluorophenoxy) phenyl] methylene-3-{4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl}-2-thioxo-4-thiazolidinone dihydrochloride (KSK05104) has potent, selective and metabolically stable IKKβ inhibitory activities. However, the apoptosis-inducing of KSK05104 an...

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Bibliographic Details
Main Authors: Hye-Uk Jung, Jeong-Hun Lee, Kyung-Sook Chung, Joo Young Hong, Jung-Hye Choi, Soo-Dong Kim, Eun Joo Roh, Kye Jung Shin, Kyung-Tae Lee
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
rhodanine derivative
apoptosis
colon cancer
ER stress
calcium
mitochondria
Online Access:https://www.mdpi.com/1420-3049/23/11/2895

Internet

https://www.mdpi.com/1420-3049/23/11/2895

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