The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NFκB and macrophage release of IL-1β

The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NFκB and macrophage release of IL-1β

The effects and mechanisms of the citrus flavonoid naringenin were investigated in a mouse model of gout arthritis induced by intra-articular injection of monosodium urate crystals (MSU). Mice were treated with naringenin (16.7–150 mg/kg, per oral) 1 h before MSU (100 µg/kg, i.a.) stimulus. MSU indu...

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Bibliographic Details
Main Authors: Kenji W. Ruiz-Miyazawa, Sergio M. Borghi, Felipe A. Pinho-Ribeiro, Larissa Staurengo-Ferrari, Victor Fattori, Glaura S.A. Fernandes, Antonio M. Casella, Jose C. Alves-Filho, Thiago M. Cunha, Fernando Q. Cunha, Rubia Casagrande, Waldiceu A. Verri, Jr
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Journal of Functional Foods
Subjects:
Naringenin
Gout arthritis
Pain
Inflammation
NFκB
Inflammasome
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464618303219

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http://www.sciencedirect.com/science/article/pii/S1756464618303219

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