Diversity and recognition efficiency of T cell responses to cancer.

Melanoma patients vaccinated with tumor-associated antigens frequently develop measurable peptide-specific CD8+ T cell responses; however, such responses often do not confer clinical benefit. Understanding why vaccine-elicited responses are beneficial in some patients but not in others will be impor...

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Bibliographic Details
Main Authors: Tor B Stuge, Susan P Holmes, Sahdev Saharan, Andrea Tuettenberg, Mario Roederer, Jeffrey S Weber, Peter P Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2004-11-01
Series:PLoS Medicine
Online Access:http://europepmc.org/articles/PMC529423?pdf=render