A drug‐repositioning screen for primary pancreatic ductal adenocarcinoma cells identifies 6‐thioguanine as an effective therapeutic agent for TPMT‐low cancer cells

A drug‐repositioning screen for primary pancreatic ductal adenocarcinoma cells identifies 6‐thioguanine as an effective therapeutic agent for TPMT‐low cancer cells

Pancreatic cancer is one of the most difficult cancers to cure due to the lack of early diagnostic tools and effective therapeutic agents. In this study, we aimed to isolate new bioactive compounds that effectively kill pancreatic ductal adenocarcinoma (PDAC) cells, but not untransformed, human panc...

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Bibliographic Details
Main Authors: Inki Kim, Yeon‐Sook Choi, Jae Hwi Song, Eun A Choi, Sojung Park, Eun Ji Lee, Je‐Keun Rhee, Song Cheol Kim, Suhwan Chang
Format: Article
Language:English
Published: Wiley 2018-09-01
Series:Molecular Oncology
Subjects:
6‐thioguanine
drug repositioning
pancreatic ductal adenocarcinoma
patient‐derived xenograft model
thiopurine methyltransferase
Online Access:https://doi.org/10.1002/1878-0261.12364

Internet

https://doi.org/10.1002/1878-0261.12364

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