Changes in CRH and ACTH synthesis during experimental and human septic shock.

The mechanisms of septic shock-associated adrenal insufficiency remain unclear. This study aimed at investigating the synthesis of corticotropin-releasing hormone (CRH) and vasopressin (AVP) by parvocellular neurons and the antehypophyseal expression of ACTH in human septic shock and in an experimen...

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Main Authors: Andrea Polito, Romain Sonneville, Céline Guidoux, Lucinda Barrett, Odile Viltart, Virginie Mattot, Shidasp Siami, Geoffroy Lorin de la Grandmaison, Fabrice Chrétien, Mervyn Singer, Françoise Gray, Djillali Annane, Jean-Philippe Brouland, Tarek Sharshar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3207830?pdf=render