WDR79/TCAB1 plays a conserved role in the control of locomotion and ameliorates phenotypic defects in SMA models

WDR79/TCAB1 plays a conserved role in the control of locomotion and ameliorates phenotypic defects in SMA models

SMN (Survival Motor Neuron) deficiency is the predominant cause of spinal muscular atrophy (SMA), a severe neurodegenerative disorder that can lead to progressive paralysis and death. Although SMN is required in every cell for proper RNA metabolism, the reason why its loss is especially critical in...

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Bibliographic Details
Main Authors: Maria Laura Di Giorgio, Alessandro Esposito, Paolo Maccallini, Emanuela Micheli, Francesca Bavasso, Ivan Gallotta, Fiammetta Vernì, Fabian Feiguin, Stefano Cacchione, Brian D. McCabe, Elia Di Schiavi, Grazia Daniela Raffa
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Neurobiology of Disease
Subjects:
SMN
SMA
WDR79/TCAB1
Drosophila melanogaster
Caenorhabditis elegans
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117301080

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http://www.sciencedirect.com/science/article/pii/S0969996117301080

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