Growth Arrest-Specific 6 Enhances the Suppressive Function of CD4+CD25+ Regulatory T Cells Mainly through Axl Receptor

Background. Growth arrest-specific (Gas) 6 is one of the endogenous ligands of TAM receptors (Tyro3, Axl, and Mertk), and its role as an immune modulator has been recently emphasized. Naturally occurring CD4+CD25+ regulatory T cells (Tregs) are essential for the active suppression of autoimmunity. T...

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Bibliographic Details
Main Authors: Guang-ju Zhao, Jia-yi Zheng, Jia-lan Bian, Long-wang Chen, Ning Dong, Yan Yu, Guang-liang Hong, Arvine Chandoo, Yong-Ming Yao, Zhong-qiu Lu
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2017/6848430