Molecular features and vulnerabilities of recurrent chordomas

Molecular features and vulnerabilities of recurrent chordomas

Abstract Background Tumor recurrence is one of the major challenges in clinical management of chordoma. Despite R0-resection, approximately 50% of chordomas recur within ten years after initial surgery. The underlying molecular processes are poorly understood resulting in the lack of associated ther...

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Bibliographic Details
Main Authors: Carolin Seeling, André Lechel, Michael Svinarenko, Peter Möller, Thomas F. E. Barth, Kevin Mellert
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Chordoma
Cell lines
Progression model
HOX
PBX
Apoptosis
Online Access:https://doi.org/10.1186/s13046-021-02037-y

Internet

https://doi.org/10.1186/s13046-021-02037-y

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